System trade starting with Python3: Bio-health stocks to look at in the new Corona

Database: COVID-19 Studies from the World Health Organization Database

Summary of development trends of new coronavirus therapeutic agents and vaccines [COVID-19](UPDATE on May 22) When will the new coronavirus vaccine be available? Vaccine types and their constituents Global Vaccine Market Features and Trends WHO Catching Up to Coronavirus: Top 60 Treatments in Development The virus that causes COVID-19 is named "SARS-CoV-2". So far, there are no specific vaccines or medicines that are effective against COVID-19. Both are under research and development.

Vaccine development is very expensive and time consuming. Only four pharmaceutical makers can withstand that risk: Pfizer, Merck, GlaxoSmithKline and Sanofi. Therefore, government subsidies are also substantial in this area. These include the Biomedical Advanced Research and Development Agency (BARDA) and the Coalition for Epidemic Infectious Diseases Inovation (CEPI).

Global pharmaceutical companies

Top Ten Pharmaceutical Companies in the World (Sales Base December 2019 Financial Results)

Reference: https://answers.ten-navi.com/pharmanews/18365/ Other references: https://www.value.today/world-top-companies/health-care

First, let's download the stock price and make a graph. Get ready first.

Jupyter notebook and pandas-datareader are recommended for downloading data using Python3. For the installation of jupyter notebook, refer to System trade starting with Python3: Installing Jupyter notebook. There are also instructions for installing pandas-datareader here. Also, please refer to I downloaded the stock price from Yahoo Finance US.

%matplotlib inline 
import matplotlib.pyplot as plt #Drawing library
import pandas_datareader.data as web #Data download library
import numpy as np
import pandas as pd
import seaborn as sns

Next, download and visualize the TOP10 stock prices.

TOP10=['RHHBY','PFE','NVS','MRK','GSK','JNJ','SNY','ABBV','TAK','BMY']
i=1
for asset in TOP10:
    tsd = web.DataReader(asset,"yahoo","1980/1/4").dropna()#jpy
    tsd=tsd/tsd.iloc[0]
    ts=np.log(tsd.loc[:,'Adj Close'].dropna())
    (ts).plot(label=str(asset))
    print(asset,adfuller((ts),regression='nc')[1:3],
      adfuller((ts),regression='c')[1:3],
      adfuller((ts),regression='ct')[1:3],
      adfuller((ts),regression='ctt')[1:3])
    if i==5:
        plt.legend()
        plt.show()
        i=0
    i+=1

The ETF that invests in well-known bio-related stocks in the United States is IBB. Since the profitability of bio stocks became a problem as part of the election campaign by Hillary Clinton in 2015, it has been on a downward trend.

tsd = web.DataReader("IBB","yahoo","2009/1/4").dropna()#jpy
np.log(tsd.loc[:,'Adj Close']).plot()

A well-known healthcare-related ETF in the United States is XLV.

tsd = web.DataReader("xlv","yahoo","2009/1/4").dropna()#jpy
np.log(tsd.loc[:,'Adj Close']).plot()

New coronavirus related

Companies and partners associated with coronavirus in the development of therapeutic agents

Companies and partners associated with coronavirus in vaccine development

Companies and partners associated with coronavirus in the development and manufacture of therapeutics and vaccines

About vaccine

"Basic concept of vaccination" wants to learn the basic knowledge of vaccines This is the most recommended material for people.

Coronavirus vaccines have been developed using a variety of technologies. Most of these vaccines are treated with so-called spike proteins, which help the SARS-CoV-2 coronavirus invade human cells. The immune system can grab spike proteins and make antibodies that stop the virus from entering. Coronavirus vaccines tell people's immune system to make antibodies to the virus without causing disease. Vaccines are composed of whole pathogens or parts of pathogens, and are classified into attenuated vaccines (live vaccines), inactivated vaccines, recombinant subunit vaccines, toxoids, and polysaccharide-protein-binding vaccines.

Viral vaccine consisting of all pathogens

A vaccine that modifies the entire coronavirus to function the immune response.

Inactivated and live attenuated vaccines

Most vaccines used today incorporate inactivated or attenuated viruses that cannot cause the disease. When immune cells recognize them, they make antibodies.

Making these vaccines often means growing the virus. Influenza vaccines are usually raised in chicken eggs, while other vaccines are raised in tanks full of floating cells. These steps can take months to produce a new vaccine.

Example: All conventional vaccines for flu, chickenpox, measles, mumps and rubella fall into this category.

Vaccine consisting of a part of the pathogen

Many of these are inactivated vaccines.

Viral vector vaccine

A vaccine that uses a virus to deliver a coronavirus gene to cells.

Vaccines that use adenovirus or other viruses

The virus is very good at invading cells. Since the 1990s, researchers have been researching ways to use these properties to deliver genes to cells and protect people from disease.

A virus called adenovirus, to which the corona spike protein gene has been added, invades cells and unloads the gene. Adenovirus lacks one of its own genes, so it cannot replicate itself and is therefore safe.

Examples: rabies and distemper, H.I.V., Ebola vaccine.

Protein-based vaccine

A vaccine that uses a coronavirus protein or protein fragment.

Virus-like particle vaccine

Some vaccines are particles that contain fragments of viral proteins. They are not real viruses, so they do not cause disease, but they can show the immune system what the coronavirus proteins look like.

Example: HPV (human papillomavirus) vaccine (inactivated).

Recombinant protein vaccine

It is a precipitated inactivated vaccine that applies genetic recombination technology. The antigen produced by yeast is adsorbed on an adjuvant (aluminum salt). Coronavirus vaccines by this method contain the entire spike protein or small fragments of the protein.

Example: Shingles and hepatitis B vaccine.

Gene vaccine

A vaccine that uses part of the genetic code of the coronavirus.

DNA vaccine

Many experimental coronavirus vaccines do not deliver the entire virus. Instead, they give instructions to build viral proteins. The protein then stimulates the immune system to make antibodies, helping to strengthen other defenses against the coronavirus.

One such genetic technique is known as the DNA vaccine. The designed ring of DNA is delivered to the cell. Cells read viral genes, make copies into molecules called messenger RNA, and use mRNA to assemble viral proteins. The immune system detects proteins and begins defense.

A prototype DNA vaccine based on spike proteins works in monkeys for coronavirus.

Examples: canine melanoma and horse West Nile virus. No DNA vaccine has been approved for use in humans, but researchers are testing to see if it works for diseases such as Zika and the flu.

RNA vaccine

Some researchers want to skip DNA and instead deliver messenger RNA to cells. The cell reads the mRNA and makes spike proteins that provoke an immune response.

Both RNA and DNA vaccines can be produced faster than traditional methods.

Example: There is no approved RNA vaccine, but clinical trials for MERS and other diseases are underway.

World's Top 10 Vaccine Manufacturers

1. GlaxoSmithKline Co., Ltd.
2. Rice melook
3. Sanofi
4. US Pfizer
5. Rice Nova Bucks
6. Emergency Bio Solutions 7.CSL
7. US Inobi Offer Matthew Ticals
8. Barbarian Nordic
9. Mitsubishi Tanabe Pharma

source: statista

Clinical trial schedule

https://media.rakuten-sec.net/articles/print/26715

CORNA=['GILD','AMGN','BIIB','REGN','ADPT','ALT','BNTX','MRNA','CYDY','GSK','HTBX',
       'INO','NVAX','SNY','RHHBY','TBIO','VXRT','ALNY','VIR','JNJ','PFE','AZN','EBS']

Next, let's graph the corona.

i=1
for asset in CORNA:
    tsd = web.DataReader(asset,"yahoo","1980/1/4").dropna()#jpy
    tsd=tsd/tsd.iloc[0]
    ts=np.log(tsd.loc[:,'Adj Close'].dropna())
    (ts).plot(label=str(asset))
    plt.legend()
    print(asset,adfuller((ts),regression='nc')[1:3],
      adfuller((ts),regression='c')[1:3],
      adfuller((ts),regression='ct')[1:3],
      adfuller((ts),regression='ctt')[1:3])
    if i==5:
        plt.show()
        i=0
    i+=1

Let's change the period from 2016 onwards.

reference

wiki COVID-19 drug development wiki COVID-19 vaccine wiki Phases of clinical research